| Name | Apicularen A | ||
| PubChem CID | 10718000 | ||
| Molecular Weight | 441.5g/mol | ||
| Synonyms |
apicularen A, Apicularene A, (-)-Apicularen A, 220757-04-0, SCHEMBL82470, CHEMBL194587, HY-N12414, CS-0905323, (2Z,4Z)-N-[(E)-3-[(1S,11S,13R,15R)-7,15-dihydroxy-9-oxo-10,17-dioxatricyclo[11.3.1.03,8]heptadeca-3(8),4,6-trien-11-yl]prop-1-enyl]hepta-2,4-dienamide |
||
| Drug Type | Small molecule | ||
| Formula | C₂₅H₃₁NO₆ | ||
| SMILES | CCC=CC=CC(=O)NC=CCC1CC2CC(CC(O2)CC3=C(C(=CC=C3)O)C(=O)O1)O | ||
| InChI | 1S/C25H31NO6/c1-2-3-4-5-11-23(29)26-12-7-9-19-16-21-15-18(27)14-20(31-21)13-17-8-6-10-22(28)24(17)25(30)32-19/h3-8,10-12,18-21,27-28H,2,9,13-16H2,1H3,(H,26,29)/b4-3-,11-5-,12-7+/t18-,19+,20+,21-/m1/s1 | ||
| InChIKey | MVOORUCGKRDJFW-ZZBSXQHZSA-N | ||
| CAS Number | 220757-04-0 | ||
| ChEMBL ID | CHEMBL194587 | ||
| Toxicity | Organism | Test Type | Route(Dose) |
| Structure | 
|
Download
2D
MOL
3D
MOL
|
|
| Pair Name | Phorbol 12-myristate 13-acetate, Apicularen A | |||
| Partner Name | Phorbol 12-myristate 13-acetate | |||
| Disease Info | [ICD-11: 2C77] | Cervical cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | CASP3 | hsa836 |
| Up-regulation | Expression | PARP1 | hsa142 | |
| Down-regulation | Expression | PRKCA | hsa5578 | |
| Down-regulation | Expression | TUBA1B | hsa10376 | |
| Down-regulation | Expression | TUBB3 | hsa10381 | |
| In Vitro Model | HeLa | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_0030 |
| Result | These results suggest that the synergy between PMA and apicularen A is involved by PKCα activation and microtubule disruption, and that may inform the development of novel approaches to treat cancer. | |||
